Alternate Names Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:188.8.131.52),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms Uniprot ID P09581 Background CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product’s natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
|Clone No.||AFS98 (See Other Available Formats)|
|Isotype||Rat IgG2a, κ|
|Isotype Control||Rat IgG2a, κ Isotype Control(PE Conjugated)[2A3] [Product E-AB-F09832D]|
|Application||FCM (See the Application Description)|
|Storage Buffer||PBS with 0.05% Proclin300, 1% BSA|
|Shipping||Biological ice pack at 4 ℃|
|Stability & Storage||Keep as a concentrated solution.
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.