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Description
| Pack Size | 20 mg |
|---|---|
| Storage Temperature | -80 degree C or below |
| Note | This product is for research use only. |
| Description | 1-<wbr />Stearoyl-<wbr />2-<wbr />arachidonoyl-<wbr /><em>sn</em>-<wbr />glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-<wbr />2 positions, respectively. 1-<wbr />Stearoyl-<wbr />2-<wbr />arachidonoyl-<wbr /><em>sn</em>-<wbr />glycerol is a diacylglycerol is a potent activator of PKCα, PKCε, and PKCδ and also competitively binds to the Ras activator RasGRP. 1, 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4, 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC), which is a key regulator of signal transduction, cellular regulation, and tumor promotion. <h4><strong>References</strong></h4> 1) Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M., (1985), <a href="https://www.ncbi.nlm.nih.gov/pubmed/3155733">Exogenous sn-1, 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets</a>", <em>J. Biol. Chem. </em><strong>260</strong>, 1358-1361. 2) Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M., (1986), <a href="https://www.pnas.org/content/83/5/1184.long">Specificity and Mechanism of Protein Kinase C Activation by sn-1, 2-diacylglycerols</a>", <em>Proc. Natl. Acad. Sci. USA </em><strong>83</strong>, 1184-1188. |
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