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Description
| Pack Size | 10 mg |
|---|---|
| Storage Temperature | 4-8 degree C |
| Note | This product is for research use only. |
| Description | CYM50308 is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM - 79.1nM. It is inactive against the S1P1, S1P2, and S1P3 receptors up to 25 μM, and the S1P5 receptor up to 2.1 μM. <hr /> <h4>References</h4> 1) <a href="https://pubmed.ncbi.nlm.nih.gov/21982495/">Urbano et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z, 5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2- (alkylimino)thiazolidin-4-one chemotype, Bioorganic & Medicinal Chemistry Letters, 2011, 6739-6745.</a> 2) <a href="https://pubmed.ncbi.nlm.nih.gov/23762926/">Guerrero et al. Identification of a novel agonist of the sphingosine 1-phosphate receptor 4 (S1P4), Probe Reports from the NIH Molecular Libraries Program. http://www.ncbi.nlm.nih.gov/books/NBK143556/</a> <hr /> |
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