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Range of ELISA Kits, Antibodies, Biochemicals, Recombinant Proteins & Assay Kits
Description
| Pack Size | 25 mg |
|---|---|
| Storage Temperature | 4-8 degree C |
| Note | This product is for research use only. |
| Description | LY294002 is a selective, cell permeable, potent and specific inhibitor of phosphatidylinositol 3-kinase (IC<sub>50</sub> = 1.4 μM; purified PI 3-kinase). It does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 μM. Induces apoptosis. In intact neutrophils stimulated with fMet-Leu-Phe, LY294002 completely abolished PI 3-kinase activity at 50 μM without cell toxicity. <h4>Publications</h4> <object id="wobj-318-b-0294" type="text/html" data="https://www.bioz.com/v_widget_2_5/318/b-0294" style="width:100%; height: 96px; background-color:[RGB Color];"></object> <div id="bioz-w-pb-b-0294-div" style="width: 100%;display:none"><a id="bioz-w-pb-b-0294" style="font-size: 12px;text-decoration:none;color:transparent;" href="https://www.bioz.com/" target="_blank" rel="noopener noreferrer"><img src="https://cdn.bioz.com/assets/favicon.png" style="width:11px;height:11px;vertical-align: baseline;padding-bottom:0px;margin-left:0px;margin-bottom:0px;float:none;display:none"> Powered by Bioz</a><a style="font-size: 12px;text-decoration:none;float: right;color:transparent;" href="https://www.bioz.com/result/b-0294/product/Echelon Biosciences/?cn=b-0294" target="_blank" rel="noopener noreferrer"> See more details on Bioz</a></div> 1. <a href="http://microbialcell.com/researcharticles/a-humanized-yeast-based-toolkit-for-monitoring-phosphatidylinositol-3-kinase-activity-at-both-single-cell-and-population-levels/">Coronas-Serna JM, Fernández-Acero T, Molina M, Cid VJ. A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels. Microbial Cell. 2018;5(12):545-54</a>. 2. <a href="https://www.sciencedirect.com/science/article/pii/S0969996113002921?via%3Dihub">Chang P, Walker MC, Williams RS. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306</a>. 3. <a href="https://journals.sagepub.com/doi/10.1177/1087057112450051">Fernández-Acero T, RodrÃguez-Escudero I, Vicente F, Monteiro MCn, Tormo JR, Cantizani J, et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors. Journal of Biomolecular Screening. 2012;17(8):1018-29</a>. <hr /> |
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