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Description
| Pack Size | 5 mg |
|---|---|
| Storage Temperature | 4-8 degree C |
| Note | This product is for research use only. |
| Description | 5-quinoxilin-6-methylene-1, 3-thiazolidine-2, 4-dione (AS605240) is an ATP-competitive inhibitor of PI3-Kγ (IC<sub>50</sub> = 8 nM). It is selective for the γ-isoform (IC<sub>50</sub>: PI 3-Kα = 60 nM, PI 3-Kβ = 270 nM, PI 3-Kδ = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 μM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus. <h4>References</h4> <object id="wobj-318-b-0301" type="text/html" data="https://www.bioz.com/v_widget_2_5/318/b-0301" style="width:100%; height: 96px; background-color:[RGB Color];"></object> <div id="bioz-w-pb-b-0301-div" style="width: 100%;display:none"><a id="bioz-w-pb-b-0301" style="font-size: 12px;text-decoration:none;color:transparent;" href="https://www.bioz.com/" target="_blank" rel="noopener noreferrer"><img src="https://cdn.bioz.com/assets/favicon.png" style="width:11px;height:11px;vertical-align: baseline;padding-bottom:0px;margin-left:0px;margin-bottom:0px;float:none;display:none"> Powered by Bioz</a><a style="font-size: 12px;text-decoration:none;float: right;color:transparent;" href="https://www.bioz.com/result/b-0301/product/Echelon Biosciences/?cn=b-0301" target="_blank" rel="noopener noreferrer"> See more details on Bioz</a></div> 1) <a href="http://www.nature.com/nm/journal/v11/n9/abs/nm1284.html">M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.</a> 2) <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=Retrieve&list_uids=16127435">D.F. Barber, et al., PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus" Nature Medicine, 2005, 11, 933-935.</a> <hr /> |
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