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cKK-E12

Cat No:N-1012 10MG | Brand:Echelon Biosciences

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Description

Pack Size 10 mg
Storage Temperature 4-8 degree C
Note This product is for research use only.
Description Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED<sub>50</sub> = 0.002, 0.01, &amp; 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for <u>research use only</u> and <u>not</u> for human use. Additional information can be found <a href="https://www.echelon-inc.com/statement-on-alc-lipids/">here</a>. <h4>References</h4> Dong et al. (2014) <a href="https://www.pnas.org/content/111/11/3955.long">Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates</a>. PNAS Mar 18;111(11):3955-60 <hr />
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