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Description
Pack Size | 50 mg |
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Storage Temperature | 4-8 degree C |
Note | This product is for research use only. |
Description | ALC-0315 is an ionizable lipid which has been used to form lipid nanoparticles for delivery of RNA. ALC-0315 is one of the components in the BNT162b2 vaccine against SARS-CoV-2 in addition to ALC-0159, DSPC, and cholesterol. This is a reagent grade product, for research use only. Additional information can be found <a href="https://www.echelon-inc.com/statement-on-alc-lipids/">here</a>. <h4><strong>References</strong></h4> 1) <a href="https://pubs.acs.org/doi/10.1021/acsnano.1c04996">R. Tenchov, R. Bird, A. E. Curtze, Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement” ACS Nano, DOI: 10.1021/acsnano.1c04996.</a> 2) <a href="https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01290">K.H. Moss, P. Popova, et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol. Pharmaceutics 16, 2265–2277, DOI: 10.1021/acs.molpharmaceut.8b01290.</a> 3) <a href="https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra03491f">Y. Duan, A. Dhar, et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems” RSC Adv., 10, 26777-26791.</a> |