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Zn (II) Deuteroporphyrin IX 2, 4 bisethylene glycol
Cat No:F-H090 25MG | Brand:Echelon Biosciences
Description
| Pack Size | 25 mg |
|---|---|
| Storage Temperature | -20 degree C or below |
| Note | This product is for research use only. |
| Description | Zn (II) Deuteroporphyrin IX 2, 4 bis ethyleneglycol is an inhibitor of heme oxygenase (the enzyme that catalyzes the conversion of heme to biliverdin in the heme degradation pathway) at concentrations as low at 0.5 μM. Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair. <h4>References</h4> 1) <a href="http://www.ncbi.nlm.nih.gov/pubmed/2759552">Chernick, R. J., P. Martasek, et al. (1989). "Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin." Hepatology 10(3): 365-9.</a> 2) <a href="http://www.ncbi.nlm.nih.gov/pubmed/17822372">Jozkowicz, A., H. Was, et al. (2007). "Heme oxygenase-1 in tumors: is it a false friend?" Antioxid Redox Signal 9(12): 2099-117.</a> 3) <a href="http://www.ncbi.nlm.nih.gov/pubmed/15925276">Abraham, N. G. and A. Kappas (2005). "Heme oxygenase and the cardiovascular-renal system." Free Radic Biol Med 39(1): 1-25.</a> 4) <a href="http://jpet.aspetjournals.org/content/325/3/833.long">Kim, D. H., A. P. Burgess, et al. (2008). "Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells." J Pharmacol Exp Ther 325(3): 833-40.</a> |
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