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Description
| Pack Size | 500 ug |
|---|---|
| Storage Temperature | -20 degree C or below |
| Note | This product is for research use only. |
| Description | Phosphatidylinositol 4, 5-bisphosphate diC8 (PI(4, 5)P2 diC8) is a synthetic, purified dioctanoyl PI(4, 5)P2. Phosphoinositides (PIP<sub>n</sub>s) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K). <hr /> <b>Alternate Names:</b> D-myo-Phosphatidylinositol 4, 5-bisphosphate, Dioctanoyl Phosphatidylinositol 4, 5-bisphosphate, PtdIns(4, 5)P2 C8, PI(4, 5)P2 C8, or PIP2 Bulk discounts available, please email <a href="mailto:echelon@echelon-inc.com?subject=Bulk">echelon@echelon-inc.com</a> for information. <h4>Publications</h4> <object id="wobj-318-p-4508" type="text/html" data="https://www.bioz.com/v_widget_2_5/318/p-4508" style="width:100%; height: 96px; background-color:[RGB Color];"></object> <div id="bioz-w-pb-p-4508-div" style="width: 100%;display:none"><a id="bioz-w-pb-p-4508" style="font-size: 12px;text-decoration:none;color:transparent;" href="https://www.bioz.com/" target="_blank" rel="noopener noreferrer"><img src="https://cdn.bioz.com/assets/favicon.png" style="width:11px;height:11px;vertical-align: baseline;padding-bottom:0px;margin-left:0px;margin-bottom:0px;float:none;display:none"> Powered by Bioz</a><a style="font-size: 12px;text-decoration:none;float: right;color:transparent;" href="https://www.bioz.com/result/p-4508/product/Echelon Biosciences/?cn=p-4508" target="_blank" rel="noopener noreferrer"> See more details on Bioz</a></div> 1) <a href="http://pubs.acs.org/doi/abs/10.1021/bi972776r">Jenco, J. M., A. Rawlingson, et al. (1998). "Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins." Biochemistry 37(14): 4901-9.</a> 2) <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12857747">Campbell, R. B., F. Liu, et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4, 5-bisphosphate." J Biol Chem 278(36): 33617-20.</a> 3) <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952224/">Haider, S., A. I. Tarasov, et al. (2007). "Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis." EMBO J 26(16): 3749.</a> 4) <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21048195">Lewis, A. E., L. Sommer, et al. (2011). "Identification of nuclear phosphatidylinositol 4, 5-bisphosphate-interacting proteins by neomycin extraction." Mol Cell Proteomics 10(2): M110 003376.</a> |
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