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Ac-Asp-Gln-Met-Asp-AMC (Caspase 3 (Apopain) Substrate)
Cat No:860-22 5MG | Brand:Echelon Biosciences
Description
| Pack Size | 5 mg |
|---|---|
| Storage Temperature | -20 degree C or below |
| Note | This product is for research use only. |
| Description | CAS Number: 355137-38-1 Molecular Weight: 706.23 Salt Form: TFA Purity: >96% Sequence (3-letter): Ac-Asp-Gln-Met-Asp-AMC Sequence (1-letter): Ac-DQMD-AMC Storage: -20 °C or below Ac-Asp-Gln-Met-Asp-AMC is a fluorogenic peptide substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer’s disease and proposed as a target for drug discovery. Ac-DQMD-AMC is reported to be a more specific substrate for Caspase 3 than Ac-DEVD-AMC. Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm. <h4>References</h4> 1. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9092497">Talanian, R.V. et al. (1997) “Substrate Specificities of Caspase Family Proteases” J. Biol. Chem. 272 (15): 9677–9682.</a> 2.<a href="http://www.ncbi.nlm.nih.gov/pubmed/9576951">Nagane, M. et al. (1998) “Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases” Proc. Natl. Acad. Sci. USA 95 (10): 5724–5729.</a> 3) <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583629/">Troy T. Rohn, Elizabeth Head “Caspases as Therapeutic Targets in Alzheimer’s Disease: Is It Time to “Cut” to the Chase?” Int J Clin Exp Pathol. 2009; 2(2): 108–118.</a> |
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