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Ac-Val-Glu-Ile-Asp-AMC (Caspase 6 (Mch2) Substrate)

Cat No:860-52 5MG | Brand:Echelon Biosciences

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Pack Size 5 mg
Storage Temperature -20 degree C or below
Note This product is for research use only.
Description CAS Number: 219137-97-0 Molecular Weight: 673.72 Salt Form: N/A Purity: &gt;96% Sequence (3-letter): Ac-Val-Glu-Ile-Asp-AMC Sequence (1-letter): Ac-VEID-AMC Storage: -20 °C or below Solubility: DMSO, phosphate buffer pH 7.5 Ac-VEID-AMC is a fluorogenic substrate for caspase 6 (Mch-2α), a member of the cysteine-aspartate protease family, which play a central role in the execution-phase of apoptosis. The excitation/emission maximum of AMC is 340-360/440-460 nm, respectively. Ac-VEID-AMC is based on lamin A site of cleavage. <h4>References</h4> 1. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11344045"> Benford, H.L. et al. (2001) “Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro” 28 (5): 465–473.</a> 2.<a href="http://www.ncbi.nlm.nih.gov/pubmed/14657026"> Rouaux, C. e al. (2003) “Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration” EMBO J. 22 (24): 6537–6549.</a>
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