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Ac-Trp-Glu-Ala-Asp-pNA (Caspase 1 (ICE) Substrate)
Cat No:860-63 5MG | Brand:Echelon Biosciences
Description
| Pack Size | 5 mg |
|---|---|
| Storage Temperature | -20 degree C or below |
| Note | This product is for research use only. |
| Description | Molecular Weight: 681.24 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Trp-Glu-Ala-Asp-pNA Sequence (1-letter): Ac-WEAD-pNA Storage: -20 °C or below Ac-Trp-Glu-Ala-Asp-pNA is a colorimetric substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm. |
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