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HSPC/Chol/DSPE-mPEG2000/DSPE-mPEG2000-maleimide/MPL (49/45/4/1/1, mol/mol) Liposomes
Cat No:LCC-0002-2ML | Brand:LipExoGen
Description
| Category | Liposomes |
|---|---|
| Description | Maleimide-reactive, PEGylated, with MPL Adjuvant Immunogenic PEGylated liposomes containing free maleimide functional group for maleimide-thiol conjugation, plus TLR4 agonist MPL for adjuvant activity. The liposomes are co-formulated with 1 mol% DSPE-mPEG2000-maleimide, and supplied in a pH-optimized buffer for direct conjugation of the thiol-containing molecule of choice. The liposomes also contain 1 mol% of the Toll-like receptor 4 (TLR4) agonist monophosphoryl lipid A (MPL), which is effective as an immune-stimulating adjuvant. This product is particularly useful in preclinical applications including vaccination, immunotherapy, or other areas of immunology research, especially in situations where a immunologically-active agent is meant to be administered for the purpose of stimulating an immune response. The surface-reactive maleimide head group enables the conjugation of a wide range of thiol-containing molecules, which could encompass antigens, immunomodulatory drugs (IMiDs), nucleic acids, or other investigational agents. In addition, the liposome vehicle is very similar to that of the well-characterized Doxil&ormulation in terms of lipid composition, which is desirable for translational purposes. We synthesize custom liposomes like this. To see a full list of our formulation capabilities, click here. Or, contact us today to request a custom formulation. |
| Note | The product is for research use only. |
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