Biotechno Labs as a proud channel-partner of Isca Biochemicals

To support endocrinological studies Biotechno Labs as a proud channel-partner of Isca Biochemicals, is glad introduce a recently launched product by Isca Biochemicals, S1H, which is a Human growth hormone receptor antagonist. Isca Biochemicals offers high quality custom and catalogue products to the worldwide life science community. Their main business is custom peptide synthesis and also have a thriving catalogue range of biochemical standards and novel research peptides for use in biological research. They currently offer research peptides for signal transduction, pain research, appetite regulation, FRET substrates, immunology research, antiviral peptides, neuropeptides, protease reagents, antimicrobial peptides and kinase reagents. Their products are being cited by researchers worldwide and appearing regularly in high impact journals. 

Growth hormone receptor (GHR) is transmembrane proteins consisting of 620 amino acids. GHR exists in two forms as a full length membrane-bound receptor and as a soluble GH binding protein. GHR contains two fibronectin type III β domains in its extracellular domain, whereas the intracellular domain contains tyrosine Kinase JAK2 binding sites for SH2 proteins. JAK2 is the primary signal transducer for growth hormone. S1H is a 16-residue peptide designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type human growth hormone (hGH). S1H acts as an inhibitor by blocking the interaction of hGH with the human growth hormone receptor (hGHR). S1H mitigates phosphorylation of STAT5 in cells co-treated with hGH, reducing intracellular STAT5 phosphorylation levels to those of untreated controls.  S1H can be used as a chemical tool to study the molecular nature of hGH–hGHR interactions.