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A 769662

SKU: BTL-IB-P-00029 | Brand: Isca Biochemical

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Product Description

Cat Number	KS-290
Category	Peptide
Pack Size	5 mg
Description	AMPK activator
Purity	98% by HPLC, NMR conforms
Biomarker Target	Kinases
Sequence Three Letter Code	4-Hydroxy-3-(2€²-hydroxy-[1,1€²-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Molecular Formula	C20H12N2O3S
Solubility	Soluble in DMSO up to 30 mg/ml or in ethanol up to 5 mg/ml
Appearance	White solid
Storage	Store dry, frozen and in the dark
References	Cool et al (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3(6) 403 PMID: 16753576Scott et al (2008) Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol. 15(11) 1220 PMID: 19022182Vazquez-Martin et al (2012) Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Cell Cycle 5 974 PMID: 2233578Ducommun et al (2014) Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662. Am J Physiol Endocrinol Metab. 306(6) E688 PMID: 24425763Abdallah and Alzahrani (2021) A-769662 stimulates the differentiation of bone marrow-derived mesenchymal stem cells into osteoblasts via AMP-activated protein kinase-dependent mechanism. J Appl Biomed. 19(3) 159 PMID: 34907759 Related areas All small molecules >All kinase modulators >All diabetes research categories >All stem cell research categories >
Note	The product is for research use only

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