Product Description
| Cat Number | HB796016 |
|---|---|
| Category | Biosimilar |
| Pack Size | 100 ug |
| Description | Varlilumabisafullyhumanmonoclonalantibody(mAb)thattargetsCD27,acriticalmoleculeintheactivationpathwayoflymphocytes.LikeCD40,CD27canbeeffectivelymanipulatedwithactivatingantibodiestoinducepotentanti-tumorresponses,andmayresultinlesstoxicitiesduetoitsrestrictedexpressionandregulation.Varlilumabisanovel,first-in-class,agonistCD27antibodythatstimulatestheCD27pathway,whichresultsinT-cellactivationandantitumoractivityintumormodels.Thisfirst-in-human,dose-escalationandexpansionstudyevaluatedthesafety,pharmacology,andactivityofvarlilumabinpatientswithadvancedsolidtumors. |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | CD27Lreceptor,TNFRSF7,T14,CD27antigen,Tumornecrosisfactorreceptorsuperfamilymember7,CD27,T-cellactivationantigenCD27 |
| Clonality | Monoclonal |
| Synonyms | 1F5,CDX-1127,CAS:1393344-72-3 |
| Host | Human |
| Concentration | 2mg/ml |
| Isotype | IgG1-kappa |
| Form | Liquid |
| Purity | >95% as determined by SDS-PAGE. |
| Specie Reactivity | Human |
| Storage | 0.01M PBS, pH7.4. |
| Note | The product is for research use only |
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