Product Description
| Cat Number | HB996016 |
|---|---|
| Category | Biosimilar |
| Pack Size | 100 ug |
| Description | Coltuximabravtansine(SAR3419)isanantibody-drugconjugate(ADC)targetingCD19createdbyconjugatingaderivativeofthepotentmicrotubule-actingcytotoxicagent,maytansine,toaversionoftheanti-CD19antibody,anti-B4,thatwashumanizedasanIgG1byvariabledomainresurfacing.Fourdifferentlinker-maytansinoidconstructsweresynthesized(average∼3.5maytansinoids/antibodyforeach)toevaluatetheimpactoflinker-payloaddesignontheactivityofthemaytansinoid-ADCstargetingCD19.Anti-CD19humanizedmonoclonalantibodyconjugatedtoDM4. |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | CD19,DifferentiationantigenCD19,T-cellsurfaceantigenLeu-12,B-lymphocyteantigenCD19,B-lymphocytesurfaceantigenB4 |
| Clonality | Monoclonal |
| Synonyms | SAR3419,CAS:1269764-99-9 |
| Host | Chimeric |
| Concentration | 1mg/ml |
| Isotype | IgG1-kappa |
| Form | Liquid |
| Purity | >95% as determined by SDS-PAGE. |
| Specie Reactivity | Human |
| Storage | 0.01M PBS, pH7.4. |
| Note | The product is for research use only |
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