Product Description
| Cat Number | T11191 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). |
| Molecular Weight | 368.34 |
| Purity | 0.9516 |
| Formula | C19H14F2N4O2 |
| Smiles | Fc1ccc(NC(=O)c2cnn(c2)-c2ccccc2F)cc1NC(=O)C=C |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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