Product Description
| Cat Number | T14212 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation. |
| Molecular Weight | 533.63 |
| Purity | 0.9797 |
| Formula | C23H30F3N3O4S2 |
| Smiles | C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
Share Item: