Product Description
| Cat Number | T16143 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment. |
| Molecular Weight | 565.71 |
| Purity | 0.9907 |
| Formula | C33H39N7O2 |
| Smiles | CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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