Product Description
| Cat Number | T1666 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Fludrocortisone acetate (9α-Fludrocortisone acetate), a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and initiates transcription of glucocorticoid-responsive genes like lipocortins to inhibit phospholipase A2 (PLA2). As the acetate salt of a synthetic fluorinated corticosteroid, it exhibits anti-inflammatory and antiallergic activities. PLA2 inhibition prevents arachidonic acid release, a precursor of eicosanoids such as prostaglandins and leukotrienes, which are key mediators in the pro-inflammatory response. As a mineralocorticoid-receptor agonist, it stimulates Na+ reabsorption, water retention, and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. |
| Molecular Weight | 422.49 |
| Purity | 0.9803 |
| Formula | C23H31FO6 |
| Smiles | [H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)CC(=O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
Share Item: