Product Description
| Cat Number | T17224 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin. |
| Molecular Weight | 552.96 |
| Purity | 0.9888 |
| Formula | C28H23ClF2N4O4 |
| Smiles | Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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