Product Description
| Cat Number | T18321 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively. |
| Molecular Weight | 591.1 |
| Purity | 0.9979 |
| Formula | C28H39ClN6O6 |
| Smiles | [C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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