Product Description
| Cat Number | T1849 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells. |
| Molecular Weight | 414.46 |
| Purity | 0.9875 |
| Formula | C23H22N6O2 |
| Smiles | O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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