Product Description
| Cat Number | T19649 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1). |
| Molecular Weight | 479.92 |
| Purity | 0.98 |
| Formula | C23H22ClN7O3 |
| Smiles | C(=O)(C=1C=2C(N(C(CO)(C)C)C1)=NC(N)=NC2)C=3C=C(NC(CC4=CC=C(Cl)C=N4)=O)C=NC3 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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