Product Description
| Cat Number | T2170 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner. |
| Molecular Weight | 402.91 |
| Purity | 0.9976 |
| Formula | C22H27ClN2O3 |
| Smiles | Cl.COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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