Product Description
| Cat Number | T2310L |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/β-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3]. |
| Molecular Weight | 501.8 |
| Purity | 0.9844 |
| Formula | C22H19Cl3N8 |
| Smiles | Cl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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