Product Description
| Cat Number | T24076 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway. |
| Molecular Weight | 360.43 |
| Purity | 0.9989 |
| Formula | C21H16N2O2S |
| Smiles | Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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