Product Description
| Cat Number | T2511 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division. |
| Molecular Weight | 336.39 |
| Purity | 0.9869 |
| Formula | C19H20N4O2 |
| Smiles | CC(C)(C)c1[nH]cnc1C=c1[nH]c(=O)c(=Cc2ccccc2)[nH]c1=O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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