Product Description
| Cat Number | T27083 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene. |
| Molecular Weight | 353.41 |
| Purity | 0.9496 |
| Formula | C20H23N3O3 |
| Smiles | C(=NNC(CCCCCC(NO)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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