Product Description
| Cat Number | T3157 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and human ribonucleotide reductase (RNR) inhibitor with potential antineoplastic activity. COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail, decreasing the pool of deoxyribonucleotide triphosphates needed for DNA synthesis, leading to cell cycle arrest and growth inhibition. It may also inhibit the nuclear enzyme poly (ADP-ribose) polymerase (PARP) 1, preventing DNA repair, causing accumulation of DNA breaks, and inducing apoptosis. |
| Molecular Weight | 420.44 |
| Purity | 0.9892 |
| Formula | C22H16N2O5S |
| Smiles | Oc1ccc(cc1O)C(=O)Nc1nc(c(s1)-c1ccccc1)-c1ccc(O)c(O)c1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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