Product Description
| Cat Number | T3520 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release. |
| Molecular Weight | 402.42 |
| Purity | 0.9916 |
| Formula | C24H19FN2O3 |
| Smiles | C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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