Product Description
| Cat Number | T3560 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke. |
| Molecular Weight | 226.34 |
| Purity | 0.9819 |
| Formula | C9H6OS3 |
| Smiles | Oc1ccc(cc1)-c1cc(=S)ss1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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