Product Description
| Cat Number | T36112 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism. |
| Molecular Weight | 344.26 |
| Formula | C15H15Cl2NO2S |
| Smiles | Cl.OC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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