Product Description
| Cat Number | T36287 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets. |
| Molecular Weight | 479.43 |
| Purity | 0.9994 |
| Formula | C22H21F4N5O3 |
| Smiles | COc1ccc(F)cc1C(=O)NCc1ccc(cc1)-c1nn([C@@H](C)C(F)(F)F)c(N)c1C(N)=O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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