Product Description
| Cat Number | T38889 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC. |
| Molecular Weight | 535.63 |
| Purity | 0.9935 |
| Formula | C28H41NO9 |
| Smiles | C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@H](CC(O)=O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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