Product Description
| Cat Number | T39321 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.CC-99677 in Rat experiments demonstrated potency in both biochemical (IC 50 =156.3 nM) and cellular assays (EC 50 =89 nM). |
| Molecular Weight | 469.94 |
| Purity | 0.9987 |
| Formula | C22H20ClN5O3S |
| Smiles | CCOCc1cnc(Cl)nc1Oc1ccc2c3c4NC[C@@H](C)NC(=O)c4sc3ccc2n1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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