Product Description
| Cat Number | T39710 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER. |
| Molecular Weight | 723.9 |
| Purity | 0.9985 |
| Formula | C45H49N5O4 |
| Smiles | OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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