Product Description
| Cat Number | T3979 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors. |
| Molecular Weight | 302.41 |
| Purity | 0.971 |
| Formula | C17H26N4O |
| Smiles | CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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