Product Description
| Cat Number | T4019 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) |
| Molecular Weight | 360.43 |
| Purity | 0.9847 |
| Formula | C21H16N2O2S |
| Smiles | Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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