Product Description
| Cat Number | T41005 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo. |
| Molecular Weight | 342.35 |
| Purity | 0.9764 |
| Formula | C17H18N4O4 |
| Smiles | COc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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