Product Description
| Cat Number | T41068 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research. |
| Molecular Weight | 592.56 |
| Purity | 0.9775 |
| Formula | C32H35Cl2N5O2 |
| Smiles | COC(=O)[C@@H](Nc1nc(CN2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccccc12)C(C)C |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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