Product Description
| Cat Number | T4126 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer. |
| Molecular Weight | 336.43 |
| Purity | 0.9957 |
| Formula | C21H24N2O2 |
| Smiles | C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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