Product Description
| Cat Number | T4247 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin. |
| Molecular Weight | 505.05 |
| Purity | 0.9969 |
| Formula | C27H37ClN2O5 |
| Smiles | O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
Share Item: