Product Description
| Cat Number | T4260 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro. |
| Molecular Weight | 485.34 |
| Purity | 0.988 |
| Formula | C23H19Cl2FN6O |
| Smiles | Cl.Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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