Product Description
| Cat Number | T4361 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB with EC50 values of 0.37 and 0.47 μM, respectively. CBL0137 hydrochloride functionally inactivates the complex that promotes chromatin transcription (FACT), thereby driving effects on p53 and NF-κB and promoting cancer cell death, and when used in combination with cisplatin, CBL0137 hydrochloride has potent anticancer activity against SCLC. |
| Molecular Weight | 372.88 |
| Purity | 0.9859 |
| Formula | C21H25ClN2O2 |
| Smiles | Cl.CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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