Product Description
| Cat Number | T4364 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain. |
| Molecular Weight | 368.48 |
| Purity | 0.9903 |
| Formula | C20H28N6O |
| Smiles | CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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