Product Description
| Cat Number | T4391 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). |
| Molecular Weight | 413.22 |
| Purity | 1 |
| Formula | C14H17Cl2F3N6O |
| Smiles | Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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