Product Description
| Cat Number | T4436 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1]. |
| Molecular Weight | 309.41 |
| Purity | 0.9934 |
| Formula | C19H23N3O |
| Smiles | CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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