Product Description
| Cat Number | T4612 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes. |
| Molecular Weight | 231.04 |
| Purity | 0.9587 |
| Formula | C8H4Cl2N2O2 |
| Smiles | ON=C1C(=O)Nc2c1ccc(Cl)c2Cl |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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